Thromboxane A_2/prostacyclin and pulmonary hypertension secondary to congenital heart disease / 实用儿科临床杂志

Objective To study the relationship between TXA 2/PGI2 and pulmonary hypertension in Congenital Heart Disease(CHD).Methods The serum concentration of TXB2/6-K-PGF1? was determined in 63 patients with CHD by radioimmunoassay. Results TXB2 ，TXB2 /6-K-PGF1? increased significantly in P H,while 6-K-PGF1? decreased,the TXB2 /6-K-PGF1? varied in different PH groups(P＜0.05).Conclusion TXA2/PGI2 plays an important role in the pathogenesis of PH se- condary to CHD.